This note examines the effects of COVID-19 and subsequent economic and educational disruptions on adolescent well-being in Bangladesh. Findings show large household-level economic impacts associated with increased food insecurity, anxiety, and mental health issues among adolescents. School closures have decreased adolescents’ access to learning, increased time spent on household chores, and affected future job aspirations. The impacts are particularly large for girls and for adolescents from more vulnerable households.