PLoS Medicine is an open-access, peer-reviewed medical journal published monthly, online and in print, by the Public Library of Science (PLoS), a nonprofit organization. It is an international, multidisciplinary medical journal that aims to publish outstanding human studies that substantially enhance the understanding of human health and disease. It also aims to promote translation of basic research into clinical investigation, and of clinical evidence into practice. PLoS Medieince encourages papers that cross disciplines.